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GLP-1 Drug Shortages: Key Challenges & Path Forward


Despite FDA announcements that semaglutide and tirzepatide shortages have resolved, patients and providers still face real-world access barriers. Our latest analysis, authored by Mayur Krishna and Saman Siddique, dives into why functional shortages persist—and what strategies can help stabilize access.


Key insights:

  • Manufacturing output has expanded, but dose-strength mismatches and distribution bottlenecks continue to disrupt care.


  • Insurance coverage gaps leave some patients paying >$1,000/month, forcing discontinuation and risking clinical backsliding.


  • The compounding shutdown created affordability challenges, highlighting the urgency for policy innovation and oral GLP-1 R&D.


  • Long-term solutions include expanding global capacity, adopting value-based contracts, and prioritizing high-need patients with transparent criteria

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At Premier Pharma Mentors, we believe bridging the gap between policy, access, and innovation will be key to ensuring sustainable availability of these life-changing therapies.


📊 Listen to the full presentation to see our framework for navigating GLP-1 shortages and building resilient market access strategies.

 
 
 

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